S4 Ep178: The Impact of Hormone Therapy on DCIS with Dr. Swati Kulkarni

Women are generally told that if they have a breast cancer diagnosis, they should steer clear of estrogen. In this episode, I have a conversation with Dr. Swati Kulkarni, the lead investigator of a new study in which women with a newly diagnosed breast ductal carcinoma in situ, DCIS, were given a month’s worth of hormone therapy before standard treatment to see the impact it would have on developing cancer cells.
What DCIS is and how it is typically diagnosed.
If DCIS is considered to be a pre-cancer or a cancer
If DCIS is untreated, how often it will progress to invasive cancer
If treated, how often women with DCIS go on to develop invasive cancer?
Why this particular form of hormone therapy, conjugated estrogens and bazodoxifene (Duovee™) was used in the study
The details of the study
The results of the study
The Promise Study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.
Link to Abstract
My summary of the study on Substack
https://drstreicher.substack.com/p/can-hormone-therapy-shrink-breast
Link to Kagan episode on Duovee with Dr. Kagan
Episode 124 All Hormones Are Not Created Equal with Dr. James Simon
Dr. Streicher is on SUBSTACK DrStreicher.Substack.com
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Lauren Streicher MD, is a clinical professor of obstetrics and gynecology at Northwestern University’s Feinberg School of Medicine, the founding medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause, and a Senior Research Fellow of The Kinsey Institute, Indiana University. She is a certified menopause practitioner of The Menopause Society. She is the Medical Director of Community Education and Outreach for Midi Health.
Dr. Streicher is the medical correspondent for Chicago’s top-rated news program, the WGN Morning News, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr. Radio, Nightline, Fox and Friends, The Steve Harvey Show, CBS This Morning, ABC News Now, NBCNightlyNews,20/20, and World News Tonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine, and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.
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Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist’s guide to eliminating post-menopause dryness and pain
Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat
Sex Rx- Hormones, Health, and Your Best Sex Ever
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