Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4

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In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life.
Dr. Sinclair shares an exclusive update on ER-100, including his team's successful restoration of vision in non-human primates and the launch of the world's first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy.
Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain.
Whether you're interested in longevity, brain health, or protecting your eyesight, this episode provides an evidence-based look at the biology of vision and the future of regenerative medicine.
00:00 AI & the First Human Clinical Trial to Reverse Aging
08:30 How the Eye Works
16:00 How Light Sets Your Body Clock
20:18 Your Eyes Are Part of Your Brain
21:34 Can Your Eyes Estimate Your Biological Age?
23:43 Can Eye Exams Help Predict Alzheimer's Disease?
24:43 ER-100: Restoring Vision Through Age Reversal
33:17 Why We Lose Vision as We Age
39:32 How to Keep Your Eyes Healthy as You Age
41:53 The Best Foods & Supplements for Eye Health
49:15 Can Diet & Fasting Protect Your Vision?
53:28 Why Violet Light Matters for Eye Health
59:28 Repairing Eye Damage: UV Light, Smoking & Alcohol
03:45 NASA's Space Mice & Swimming Goggles
05:59 Are You Genetically Predisposed to Eye Disease?
07:48 What's Next in Age Reversal Research?
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