Plasma Cell Disorders | Ninja Nerd

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Ninja Nerds!
Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström macroglobulinemia, as well as the role of paraproteins and their clinical implications. We discuss diagnostic approaches such as serum protein electrophoresis (SPEP), immunofixation, and bone marrow biopsy, along with treatment options like proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. We also explore complications like hypercalcemia, renal impairment, anemia, and bone lesions, ensuring a high-yield overview for exams and clinical practice. Enjoy the episode, and support us below!
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Hosts

Rob Beach
Zach Murphy