The Man Who Invented Klotho & FLGR-242 – Michael Farber Pt. 1 | Peptide of the Week Podcast

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This is not a conversation about peptides. This is a conversation with the man who invented two of the most talked about longevity compounds on the planet. Dr. Michael Farber joins JD Denham and William T. Haas to break down Klotho and FLGR-242 from the ground up. Who created them, why he created them, how they actually work in the body, and where medicine is heading in the next 20 years.
🔬 Topics Covered:
• Who is Dr. Michael Farber and his 35 years in biochemistry and 150 patents
• Why he invented Klotho to save his own kidney after losing his right kidney in his teens
• How Klotho regulates phosphate and calcium and why that matters for kidney function
• The feedback loop of kidney disease that has never been reversible until now
• People going from an EGFR of 40 back up to 70 and beyond on Klotho
• Why Klotho makes NAD work dramatically better through the SIRT1 pathway
• Klotho and the blood brain barrier: clearing toxic plaque buildup without entering the brain
• Why Dr. Farber considers Klotho more important for longevity than FLGR-242
• How the albumin binder platform works and why it allows bi-weekly dosing
• Klotho dosing: 10 micrograms every two weeks for healthy individuals, every 11 to 12 days for kidney dysfunction
• What happens if you overdose Klotho and why it is strictly range-bound
• FLGR-242: the long-acting myostatin inhibitor that is outperforming all expectations
• Why FLGR-242 dosing is nothing like Follistatin-344 and must not be confused
• The future of medicine: synthetic organs, CRISPR, fetal genetic optimization, and living to 120
• Dr. Farber consumed a bottle of painkillers a week for decades. In the last 18 months he has taken two or three total.
Chapters:
00:00 – Cold Open: Living With Kidney Disease for 40 Years
00:45 – Intro
00:54 – Welcome Back & Meeting Dr. Michael Farber
02:50 – Why He Created Klotho: Losing a Kidney
05:10 – Klotho Results: 10 mcg & Rising eGFR
07:34 – The Albumin Binder Breakthrough
12:28 – How Klotho Works in the Body
14:53 – Klotho, NAD+ & FLGR-242 Synergy
20:13 – Cardiovascular Health & Restored Libido
21:54 – Klotho Dosing: 10 mcg Every 11–14 Days
24:52 – Separating Hype From Reality
27:14 – Overdose Risks & Checking Urine Output
29:42 – Feeling "Reborn": Life After Kidney Disease
36:30 – The Future of Longevity: Organs & CRISPR
45:12 – Outro & Part 2 Preview
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