Apr 17 2026 This Week in Cardiology

SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ACC: SPIRIT-HF Trial
FINEARTS-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
TOPCAT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
TOPCAT Americas Trial https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255
II A New Class of Lipid Lowering Drug Has a Dubious Debut At ACC
ESSENCE-TIMI 73b Imaging Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080012
ESSENCE-TIMI 73b Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2507227
IMPROVE IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1410489
III Drug-Coated Balloons Looked Quite Good in PAD interventions
Sirolimus-Coated Balloon Reduces Amputation Risk in Peripheral Artery Disease
https://www.medscape.com/viewarticle/sirolimus-coated-balloon-reduces-amputation-risk-peripheral-2026a1000a83
SirPAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600360
IV Another Vascular Story from the European Heart Rhythm Association
ULYSSES Trial https://doi.org/10.1093/eurheartj/ehag291
ULTRA-FAST Trial https://doi.org/10.1093/europace/eux175
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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