Mar 27 2026 This Week in Cardiology

Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Early AVR
RECOVERY Trial at 10 Years https://www.nejm.org/doi/full/10.1056/NEJMoa2511920
II Major Bleeding with Amulet and Watchman in JAMA Cardiology
Amulet IDE Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2847047
5-year Results From Amulet IDE https://www.jacc.org/doi/10.1016/j.jacc.2024.10.101
III ACC Preview
Mandrola's Top 4 Trials from ACC 2026: Details Matter
https://www.medscape.com/viewarticle/mandrolas-top-4-trials-acc-2026-details-matter-2026a10008ti
CHIB-BCIS3 Trial https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013367
Champion-AF Protocol https://doi.org/10.1016/j.ahj.2023.05.022
ORBITA-CTO Protocol Paper https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1172763/full
SPIRIT-HF Clinical Trials.gov https://clinicaltrials.gov/study/NCT04727073
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