Nov 21 2025 This Week in Cardiology

Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1
II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published
ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext
SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/
CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800
CREST Protocol paper https://pmc.ncbi.nlm.nih.gov/articles/PMC5987521/
III Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
PLATO trial https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
Ticagrelor or prasugrel vs clopidogrel in PCI https://eurointervention.pcronline.com/article/ticagrelor-or-prasugrel-versus-clopidogrel-in-patients-undergoing-percutaneous-coronary-intervention-for-chronic-coronary-syndromes
ISAR-REACT 5 trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
IV Another Coffee and AF study
Can Coffee Cut the Risk for Atrial Fibrillation?
https://www.medscape.com/viewarticle/can-coffee-cut-risk-atrial-fibrillation-2025a1000w11
A Coffee a Day to Keep the AFib Away? The DECAF Trial Discussed https://www.medscape.com/viewarticle/coffee-day-keep-afib-away-decaf-trial-discussed-2025a1000v5z
DECAF trial https://jamanetwork.com/journals/jama/fullarticle/2841253
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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