Oct 23, 2026 This Week in Cardiology Podcast

Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf
Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/
II More on Nonobstructive HCM
Communication on Post-Hoc Analysis of ODYSSEY (mavacamten)
Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092
III Complete vs Staged PCI in STEMI With Multivessel Disease
Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033
Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650
FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763
iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020
MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823
OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link
CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease
Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
IV A Call to Action for Electrophysiologists
Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023
EP at a Crossroads - Josephson 2007 https://doi.org/10.1016/j.hrthm.2006.12.045
EP at a Crossroads: A Revisit - Josephson 2016 https://doi.org/10.1016/j.hrthm.2016.07.024
V FDA Approves Another Tricuspid Valve Repair System
Press release https://www.edwards.com/newsroom/news/2026-10-21-fda-approval-of-edwards-lifesciences--pascal-preci
TRIC I HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
CLASP II TR Trial https://pubmed.ncbi.nlm.nih.gov/42855029/
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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